Effect of physicochemical features of biomimetic hydroxyapatite on endothelial cell behaviour
نویسنده
چکیده
INTRODUCTION: Calcium Phosphates (CaPs) such as biomimetic hydroxyapatite (bHA) have been extensively used as bone substitutes due to their similarity to the mineral phase of bone. However, the success of bone graft and subsequently bone regeneration depends mainly on postimplaiting neovascularization/ angiogenesis process [1]. Therefore, the knowledge of endothelial cell behavior in contact with CaPs is crucial for the further improvement of the materials. The aim of this study was to evaluate rat endothelial progenitor cells (rEPCs) behavior in contact with bHA. In vitro assays were performed varying the porosity, specific surface area (SSA) of bHA as well as its surface morphology in order to reveal their effect on rEPCs.
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